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Neurotoxicology

WIL Research approaches neuroscience as an interdisciplinary effort that seeks to understand the relationship between the nervous system and behavior, and involves the collaborative efforts of our scientists who study behavior, chemistry, anatomic pathology and physiology. Specialized techniques are used not only to study how the brain directs behavior, but also in neurotoxicology, to describe and predict the consequences for behavior following insult to the nervous system.

At WIL, our rich scientific history has yielded extensive and comprehensive databases in both adult and developmental neurotoxicity that allow our scientists to interpret the results of a wide array of testing paradigms. In addition, dedicated well-designed laboratories with state-of-the-art equipment are available to meet our clients' neurotoxicity testing requirements for both small and large animals.

Finally, because a number of our neuroscience projects are unique and involve "leading-edge" science, WIL maintains working collaborations with several prestigious universities around the country.

Capabilities

Behavior

• Functional Observational Battery (FOB)
• Automated spontaneous locomotor activity
• Rota-rod forced activity
• Maze learning and memory paradigms
• Auditory startle habituation
• Analgesia screening
• Neurological evaluations of dams and progeny
• Developmental physical landmark assessments

Neurochemistry

• Cholinesterase assays for red blood cell, plasma and brain sampling
• Quantification of endogenous levels of brain neurotransmitters, such as dopamine, norepinephrine and serotonin

Neuropathology

• In situ perfusion
• Paraffin and plastic embedding
• Routine and specialized staining
• Morphometry
• Nerve fiber teasing
• Qualitative neuropathological evaluations

Specialized Paradigms

• Drug abuse/dependence liability testing
• Ototoxicity
• Electrophysiology
• Nerve conduction velocity
• EEG
• Evoked responses

Applications

Adult Neurobehavioral and Neuropathological Assessment

• Acute, subchronic and chronic studies
• Delayed neurotoxicity of organo-phosphorous compounds

Developmental Neurobehavioral Assessment

• Pre - and postnatal development (ICH 4.1.2)
• Developmental neurotoxicity studies, including neuropathological evaluations.
• Data call-ins

Juvenile Studies for FDA package insert requirements