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Pathology

WIL Research employs an experienced team of board-certified veterinary pathologists and technical support staff to provide accurate and thorough assessments of pathologic changes that are so critical to toxicity safety assessment studies. Significant expertise is provided in the evaluation of pharmaceutical, agrochemical, and chemical compounds administered via all routes of exposure. A broad array of services for all laboratory models is available in the disciplines of necropsy, histology, clinical and anatomic pathology. All are conducted in state-of-the-art laboratories in compliance with Good Laboratory Practices (GLP) regulation.

Capabilities

Histopathology

• Evaluation of acute, subchronic, chronic and oncogenicity, developmental and reproduction studies
• Immunohistochemistry
• Neuropathology, including developmental neuropathology
• Evaluation of implants and devices
• Cell proliferation assays (BrdU and PCNA)
• Morphometry
• Oocyte enumeration and spermatogenesis staging
• Historical control database for most laboratory models and strains
• Formal peer review/pathology working groups
• Digital imaging/routine photomicrography
• Completely automated and integrated data collection and reporting

Histology

• Paraffin, frozen and plastic sections
• Immunohistochemstry
• Special stains
• Large-tissue sectioning
• Discrete brain sectioning (Bregma levels)

Clinical Pathology

• Over 45 serum/urine chemistry tests available
• T3/T4, TSH, cortisol, insulin, testosterone, prolactin, progesterone, LH and ACTH assays
• Complete hematology and urinalysis
• Tissue analyses, including cholinesterase and phospholipids
• Coagulation and chromogenic assays
• Blood gas/co-oximetry

Necropsy

• Whole- and upper- body perfusions in all models
• Constant-pressure lung infusion
• Tissue collection and preparation for electron microscopy and immunohistochemistry
• Full reproduction and teratogenicity studies, including laparohysterectomy
• Fetal examinations (external, visceral and skeletal)
• Sperm evaluations
• Extensive database of fetal malformations/developmental variations