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| 2010 |
Li, A.A., Maurissen, J.P.J., Barnett Jr., J.F., Foss, J., Freshwater, L., Garman, R.H., Peachee, V.L., Hong, S.J., Stump, D.G.and Bus, J.S. Oral gavage subchronic neurotoxicity and inhalation subchronic immunotoxicity studies of ethylbenzene in the rat. NeuroToxicology, 2010, in press. |
Stump, D.G; Beck, M.J., Radovsky, A.; Garman, R.H; Freshwater, L.L; Sheets, L.P.; Marty, M. S.; Waechter, Jr,, J.M.; Dimond; S.S.; Van Miller, J.P.; Shiotsuka, R.N.; Beyer, D.; Chappelle, A.; Hentges, S.G. Developmental Neurotoxicity Study of Dietary Bisphenol A in Sprague-Dawley Rats. Toxicological Sciences, 2010, in press. |
Reynolds, V.L; Stump, D.G.; Holson J.F. Assessing the toxicological significance of ejaculatory plugs as a clinical observation in rat toxicology studies: CNS-mediated increases in plug production vs. gustatory-mediated decreases in plug consumption. Reproductive Toxicology 2010, in press. |
| 2009 |
Weiner, M.L.; Nemec, M.; Sheets, L.; Sargent, D.; Breckenridge, C. Comparative functional observational battery study of twelve commercial pyrethroid insecticides in male rats following acute oral exposure. Neurotoxicology 2009, 30(1), S1-16. |
Morita, O.; Knapp, J.F.; Tamaki, Y.; Stump, D.G.; Nemec, M.D.; Yoshimura, K. Safety studies of pseudo-ceramide SLE66. Part 3: Effects on embryo/fetal development in rats. Food and Chemical Toxicology 2009, 47, 681-686. |
Chang, S.; Ehresman, D.J.; Bjork, J.A.; Wallace, K.B.; Parker, G.A.; Stump, D.S.; Butenhoff, J.L. Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: Toxicokinetics, thyroid hormone status, and related gene expression. Reproductive Toxicology 2009, 27, 387-399. |
Morita, O.; Knapp, J.F.; Tamaki, Y.; Stump, D.G.; Moore, J.S.; Nemec, M.D. Effects of green tea catechin on embryo/fetal developments in rats. Food and Chemical Toxicology 2009, 47, 1296-1303. |
Butenhoff J.L.; Ehresman, D.J.; Chang, S.C.; Parker, G.A.; Stump, D.G. Gestational and lactational exposure to potassium perfluorooctanesulfonate (K(+) PFOS) in rats: Developmental neurotoxicity. Reproductive Toxicology 2009, 27(3-4), 319-30. |
Wise, L.D.; Buschmann, J.; Feuston, M.H.; Fisher, J.E.; Hew, K.W.; Hoberman, A.M.; Lerman, S.A.; Ooshima, Y.; Stump, D.G. Embryo-fetal developmental toxicity study design for pharmaceuticals. Birth Defects Research (Part B) 2009, 86, 418-428. |
Lerman, S.A.; Hew, K.W.; Stewart, J.; Stump, D.G.; Wise, L.D. The nonclinical fertility study design for pharmaceuticals. Birth Defects Research (Part B) 2009, 86, 429-436. |
Cappon, G.D.; Bailey, G.P.; Buschmann, J.; Feuston, M.H.; Fisher,J.E.; Hew, K.W.; Hoberman, A.M.; Ooshima, Y.; Stump, D.G.;Hurtt, M.E. Juvenile animal toxicity study designs to support pediatric drug development. Birth Defects Research (Part B) 2009, 86, 463-469. |
Mejia, L.A.; Korgaonkar, C.K.; Schweizer, M.; Chengelis, C.; Novilla, M.; Ziemer, E.; Williamson-Hughes, P.S.; Grabiel, R.; Empie, M. A 13-week dietary toxicity study in rats of a Napin-Rich Canola Protein Isolate. Regulatory Toxicology and Pharmacology 2009, in press. |
Chengelis, C.P.; Kirkpatrick, J.B.; Radovsky, A.; Shinohara, M. A 90-day repeated dose oral (gavage) toxicity study of perfluorohexanoic Acid (PFHxA) in rats (with functional observational battery and motor activity determinations). Reproductive Toxicology 2009, 27, 342-351. |
Remick, A.K.; Van Wettere, A.J.; Williams, C.V. Neoplasia in prosimians: Case series from a captive prosimian population and literature review. Veterinary Pathology 2009, 46, 746-772. |
| Pelham, R.W.; Russell, R.G.; Padgett, E.L.; Reno, R.E.; Cleveland, M.B. Safety of oral sulfates in rats and dogs contrasted with phosphate-induced nephropathy in rats. International Journal of Toxicology 2009, 28(2), 99-112. |
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Chengelis, C.P.; Kirkpatrick, J.B.; Myers, N.R.; Shinohara, M.; Stetson, P.L.; Sved, D.W. Comparison of the toxicokinetic behavior of perfluorohexanoic acid (PFHxA) and nonafluorobutane-1-sulfonic acid (PFBS) in Cynomolgus monkeys and rats. Reproductive Toxicology 2009, 27, 400-406. |
| Nemec, M.D.; Sloter, E.D.; Stump, D.G.; Holson, J.F.; Kirkpatrick, D.T.; Kinzell, J. Prenatal developmental toxicity studies of inhaled methyl iodide vapor in rabbits reveal a susceptible window of exposure inducing late gestational fetotoxicity. Inhalation Toxicology 2009, 21(6), 449-461. |
| Sloter, E.; Nemec, M.D.; Stump, D.G.; Holson, J.F.; Kirkpatrick, D.T.; Gargas, M.; Kinzell, J. Methyl iodide-induced fetal hypothroidism implicated in late-stage fetal death in rabbits. Inhalation Toxicology 2009, 21(6), 462-479. |
| 2008 |
| Nemec, M.D.; Kirkpatrick, D.T.; Sherman, J.; Van Miller, J.P.; Pershing, M.L.; Strother, D.E. Two-generation reproductive toxicity study of inhaled acrylonitrile vapors in Crl:CD(SD) rats. Int J Toxicol. 2008 27(1), 11-29. |
Welsch, F.; Nemec, M.D.; Lawrence, W.B. Two-generation reproductive toxicity study of resorcinol administered via drinking water to Crl:CD(SD) Rats. Int J Toxicol. 2008, 27(1), 43-57. Erratum in: Int J Toxicol. 2008, 27(2), 255. |
Oller, A.R.; Kirkpatrick, D.T.; Radovsky, A.; Bates, H.K. Inhalation carcinogenicity study of nickel metal powder in Wistar rats. Toxicology Applied Pharmacology 2008, 233(2), 262-275. |
| Burns-Naas, L.A.; Hasting, K.L.; Ladics, G.S.; Makris, S.L.; Parker, G.A.; Holsapple, M.P. What's so special about the developing immune system? International Journal of Toxicology 2008, 27, 223-254. |
| Chengelis, C.P.; Kirkpatrick, J.B.; Regan, K.S.; Radovsky, A.E.; Beck, M.J.; Morita, O.; Tamaki, Y.; Suzuki, H. 28-Day oral (gavage) toxicity studies of green tea catechins prepared for beverages in rats. Food and Chemical Toxicology 2008, 46(3), 978-989. |
| Connelly, P.W.; Maguire, G.F.; Picardo, C.M.; Teiber, J.F.; Draganov, D.I. Development of an immunoblot assay with infrared fluorescence to quantify paraoxonase 1 in serum and plasma. Journal of Lipid Research 2008, 49, 245-250. |
| Hammond, B.G.; Lemen, J.K.; Ahmed, G.; Miller, K.D.; Kirkpatrick, J.B.; Fleeman, T.L. Safety assessment of SDA soybean oil: Results of a 28-day gavage study and a 90-day/one-generation reproduction feeding study in rats. Regulatory Toxicology and Pharmacology 2008, 52, 311-323. |
| Healy, C.; Hammond, B.; Kirkpatrick, J. Results of a 13-week safety assurance study with rats fed grain from corn rootworm-protected, glyphosate-tolerant MON 88017 corn. Food and Chemical Toxicology 2008, 46, 2517-2524. |
| MacElrevey, C.; Salter, J.D.; Krucinska, J.; Wedekind, J.E. Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme. RNA 2008, 14, 1600-1616. |
| Miller, W.R.; Snyder, L.T.; Chengelis, C.P.; Parker, G.A.; Wally, R.A. Auricular chondropathy in rats at a contract research toxciology laboratory. Toxicology Mechanisms and Methods 2008, 18, 35-39. |
| Morita, O.; Knapp, J.F.; Tamaki, Y.; Varsho, B.J.; Stump, D.G.; Nemec, M.D. Effects of dietary diacylglycerol oil on embryo/fetal development in rats. Food and Chemical Toxicology 2008, 46, 2510-2516. |
| Morita, O.; Knapp, J.F.; Tamaki, Y.; Nemec, M.D.; Varsho, B.J.; Stump, D.G. Safety assessment of dietary diacylglycerol oil: A two-generation reproductive toxicity study in rats. Food and Chemical Toxicology 2008, 46, 3059-3068. |
| Nikiforov, A.; Eapen, A.K. A 90-day oral (dietary) toxicity study of rebaudioside A in Sprague Dawley rats. International Journal of Toxicology 2008, 27, 65-80. |
| Pelham, R.W.; Nix, L.C.; Chavira, R.E.; Cleveland, M.V.B.; Stetson, P.L. Clinical trial: Single- and multiple-dose pharmacokinetics of polyethylene glycol (PEG-3350) in health young and elderly subjects. Alimentary Pharmacology & Therapeutics 2008, 28, 256-265. |
| Shuey, D.L.; Stump, D.G.; Carliss, R.D.; Gerson, R.J. Effects of the opioid analgesic oxymorphone hydrochloride on reproductive function in male and female rats. Birth Defects Research Part B 2008, 83, 12-18. |
| Stump, D.G.; Holson, J.F.; Murphy, S.R.; Farr, C.H.; Schmit, B.; Shinohara, M. An oral two-generation reproductive toxicity study of S-111-S-WB in rats. Reproductive Toxicology 2008, 25, 7-20. |
| Teiber, J.F.; Horke, S.; Haines, D.C.; Chowdhary, P.K.; Xiao, J.; Kramer, G.L.; Haley, R.W.; Draganov, D.I. Dominant role of paraoxanases in the inactivation of the Pseudomonas aeruginosa quorum sensing signal N-(3-Oxododecanoyl)-L-Homoserine lactone. Infection and Immunity 2008, 76(6), 2512-2519. |
| 2007 |
| Roegge, C.S.; Perraut, C.; Hao, X.; Levin, E.D. Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine. Pharmacology Biochemistry and Behavior 2007, 86(4), 686-692. |
| Harris, W.S.; DiRienzo, M.A.; Sands, S.C.; George, C.; Jones, P.G.; Eapen, A.K. Stearidonic acid increases the red blood cell and heart eicosapentaenoic acid content in dogs. Lipids 2007, 42, 325-333. |
| Faber, W.D.; Deyo, J.A.; Stump, D.G.; Ruble, K. Developmental toxicity and uterotrophic studies with Di-2-ethylhexyl terephthalate. Birth Defects Research Part B 2007, 80, 69-81. |
| Eapen, A.K.; Chengelis, C.P.; Jordan, N.P.; Baumgartner, R.E.; Zheng, G.H., Carlson, T. A 28-day oral (dietary) toxicity study of Sucromalt in Sprague Dawley rats. Food and Chemical Toxicology 2007, 45, 2304-2311. |
| Carliss, R.D.; Radovsky, A.; Chengelis, C.P.; O'Neill, T.P.; Shuey, D.L. Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain. NeuroToxicology 2007, 28, 813-818. |
| Sloter, E.D.; Marchetti, F.; Eskenazi, B.; Nath, J.; Weldon, R.H.; Wyrobek, A.J.; Cabreros, D. Frequency of human sperm carrying structural aberrations of chromosome 1 increases with advancing age. Fertility and Sterility 2007, 87(5), 1077-86. |
| Doull, J.; Borzelleca, J.F.; Becker, R.; Daston, G.; DeSesso, J.; Fan, A.; Fenner-Crisp, P.; Holsapple, M.; Holson, J.; Llewellyn, G.C.; MacGregor, J.; Seed, J.; Walls, I.; Woo, Y.; Olin, S. Framework for use of toxicity screening tools in context-based decision-making. Food and Chemical Toxicology 2007, 45, 759-796. |
| Faber, W.D.; Deyo, J.A.; Stump, D.G.; Ruble, K. Two-generation reproduction study of Di-2-Ethylhexyl Terephthalate in Crl:CD rats. Birth Defects Research Part B 2007, 80, 69-81. |
| Siddiqui, W.H.; Stump, D.G.; Plotzke, K.P.; Holson, J.F.; Meeks, R.G. A two-generation reproductive toxicity study of Octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation. Reproductive Toxicology 2007, 23, 202-215. |
| Meeks, R.G.; Stump, D.G.; Siddiqui, W.H.; Holson, J.F.; Plotzke, K.P.; Reynolds, V.L. An inhalation reproductive toxicity study of Octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimens. Reproductive Toxicology 2007, 23, 192-201. |
| Siddiqui, W.H.; Stump, D.G.; Reynolds, V.L.; Plotzke, K.P.; Holson, J.F.; Meeks, R.G. A two-generation reproductive toxicity study of Decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reproductive Toxicology 2007, 23, 216-225. |
| Faber, W.D.; Roberts, L.S.G.; Stump, D.G.; Beck, M.J.; Kirkpatrick, D.T.; Regan, K.S.; Tort, M.; Moran, E.; Banton, M. Inhalation developmental neurotoxicity study of Ethylbenzene in Crl:CD rats. Birth Defects Research Part B 2007, 80, 34-48. |
| Sved, D.W.; Godsey, J.L.; Ledyard, S.L.; Mahoney, A.P.; Stetson, P.L.; Ho, S.; Myers, N.R.; Resnis, P.; Renwick, A.G. Absorption, tissue distribution, metabolism and elimination of taurine given orally to rats. Amino Acids 2007, 32(4) 459-466. |
| Teiber, J.F.; Billecke, S.S.; LaDu, B.N.; Draganov, D.I. Estrogen esters as substrates for human paraoxonases. Archives of Biochemistry and Biophysics 2007, 461, 24-9. |
| 2006 |
McKee, R.H.; Pavkov, K.L.; Trimmer, G.W.; Keller, L.H.; Stump, D.G. An assessment of the potential developmental and reproductive toxicity of di-isoheptyl phthalate in rodents. Reproductive Toxicology 2006, 21, 241-252. |
Faber, W.D.; Roberts, L.S.; Stump, D.G.; Tardif, R.; Krishnan, K.; Tort, M.; Dimond, S.; Dutton, D.; Moran, E.; Lawrence, W. Two generation reproduction study of ethylbenzene by inhalation in Crl-CD Rats. Birth Defects Research Part B 2006, 77, 10-21. |
| Soloviev, M.V.; Hamlin, R.L.; Barrett, R.M.; Chengelis, C.P.; Schaefer, G.J. Different species require different correction factors for the QT interval. Cardiovascular Toxicology 2006, 6(2), 145-157. |
| Sloter, E.; Schmid, T.; Marchetti, F.; Eskenazi, B.; Nath, J.; Wyrobek, A.J. Quantitative effects of male age on sperm motion. Human Reproduction 2006, 21(11), 2868-75. |
| Soloviev, M.V.; Hamlin, R.L.; Shellhammer, L.J.; Barrett, R.M.; Wally, R.A.; Birchmeier, P.A.; Schaefer, G.J. Variations in hemodynamic parameters and ECG in healthy conscious freely moving telemetrized Beagle dogs. Cardiovascular Toxicology 2006, 6, 51-62. |
| 2005 |
| Cruzan, G.; Faber, W.D.; Johnson, K.A.; Roberts, L.S.; Hellwig, J.; Carney, E.; Yarrington, J.T.; Stump, D.G. Two-generation reproduction study of styrene by inhalation in Crl:CD rats. Birth Defects Research Part B 2005, 74, 211-220. |
| Bowman, C.J.; Turner, K.J.; Sar, M.; Barlow, N.J.; Gaido, K.W.; Foster, P.M.D. Altered gene expression in developing Wolffian ducts from rats following di(n-butyl) phthalate exposure. Toxicological Sciences 2005, 86, 161-174. |
| Eskenazi, B.; Kidd, S.A.; Marks, A.R.; Sloter, E.; Block, G.; Wyrobek, A.J. Antioxidant intake is associated with semen quality in healthy men. Human Reproduction 2005, 20(4), 1006-12. |
| Holson, J.F.; Stump, D.G.; Pearce, L.B.; Watson, R.E.; DeSesso, J.M. Mode of action: Yolk sac poisoning and impeded histiotrophic nutrition – HBOC-related congenital malformations. Critical Reviews in Toxicology 2005, 35, 739-745. |
| Parker, G.A.; Picut, C. Liver immunobiology. Toxicologic Pathology 2005, 33, 52-62. |
| Cruzan, G.; Faber, W.D.; Johnson, K.A.; Roberts, L.S., Hellwig, J.; Maurissen, J.; Beck, M.J.; Radovsky, A.; Stump, D.G. Developmental neurotoxicity study of styrene by inhalation in Crl:CD rats. Birth Defects Research Part B 2005, 74, 221-232. |
| 2004 |
| Nemec, M.D.; Pitt, J.A.; Topping, D.C.; Gingell, R.; Pavkov, K.L.; Rauckman, E.J.; Harris, S.B. Inhalation two-generation reproductive toxicity study of methyl isobutyl ketone in rats. International Journal of Toxicology 2004, 23, 127-143. |
| Padgett, E.L. A U.S. perspective on the off-label use, regulatory history and development of drugs in the pediatric population. Safety Evaluation Form, Dokusei Shitsumon Bako, Scientist Inc. 2004, 7, 14-30. |
| Cruzan, G.; Corley, R.A.; Hard, G.C.; Mertens, J.J.W.M.; McMartin, K.E.; Snellings, W.M.; Gingell, R.; Deyo, J.A. Subchronic toxicity of ethylene glycol in Wistar and F-344 rats related to metabolism and clearance of metabolites. Toxicological Sciences 2004, 81, 502-511. |
| Czarneski, J.; Lin, Y.C.; McCarthy, B.; Fernandez, H.; Parker, G.; Mansour, A.; Huppi, K.; Marti, G.; Raveche, E. Studies in NZB IL-10 knockout mice of the requirement of IL-10 for progression of B-cell lymphoma. Leukemia 2004, 18, 597-606. |
| Schmid, T.E.; Brinkworth, M.H.; Hill, F.; Sloter, E.; Kamischke, A.; Marchetti, F.; Nieschlag, E.; Wyrobek, A.J. Detection of structural and numerical chromosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients. Human Reproduction 2004, 19(6), 1395-400. |
Sloter, E.; Nath, J.; Eskenazi, B.; Wyrobek, A.J. Effects of Male Age on the Frequencies of Germinal and Heritable Chromosomal Abnormalities in Humans and Rodents. Fertility and Sterility 2004, 81, 925-943. |
| 2003 |
| Gleason, T.G.; Chengelis, C.P.; Jackson, C.B.; Lindstrom, P. A 24-hour continuous infusion study of bivalirudin in the rat. International Journal of Toxicology 2003, 22(3), 195-206. |
Burns-Naas, L.A.; Webber, S.; Stump, D.G.; Holson, J.F.; Masarjian, L.; Zorbas, M. Absence of embryo-fetal toxicity in rats or rabbits following oral dosing with nelfinavir. Regulatory Toxicology and Pharmacology 2003 38(3), 291-303. |
Burns-Naas, L.A.; Stump, D.G.; Webber, S.; Holson, J.F.; Masarjian, L.; Furman, G.; Zorbas, M. Absence of reproductive and developmental toxicity in rats following oral dosing with nelfinavir. Regulatory Toxicology and Pharmacology 2003, 38(3), 304-316. |
Bu, W.; Myers, N.; McCarty, J.D.; O’Neill T.; Holler, S.; Stetson, P.L.; Sved, D.W. Simultaneous determination of six urinary porphyrins using liquid chromatography - tandem mass spectrometry. Journal of Chromatography B Analytical Technologies Biomedical Life Sciences 2003, 783(2), 411-423. |
| 2002 |
| Behringer, W.; Safar, P.; Kentner, R.; Wu, X.; Kagan, V.E.; Radovsky, A.; Clark, R.S.; et al. Antioxidant tempol enhances hypothermic cerebral preservation during prolonged cardiac arrest in dogs. Journal of Cerebral Blood Flow and Metabolism 2002, 22, 105-117. |
| Padgett, E.L.; Seelig, L.L. Jr. Effects on T-cell maturation and proliferation induced by lactational transfer of cyclosporine to nursing pups. Transplantation 2002, 73, 867-874. |
| Beck, B.D.; Slayton, T.M.; Farr, C.H.; Sved, D.W.; Crecelius, E.A.; Holson, J.F. Systemic update of inhaled arsenic in rabbits. Human and Experimental Toxicology 2002, 21, 205-215. |
| 2001 |
| Hammond, B.G.; Mayhew, D.A.; Holson, J.F.; Nemec, M.D.; Mast, R.W.; Sander, W.J. Safety assessment of DHA-rich microalgae from Schizochytrium sp. Regul Toxicol Pharmacol. 2001, 33(2), 205-17. |
Varsho, B.J.; Stump, D.G.; Becker, R.A.; Owens, J.W. OECD rodent uterotrophic assay validation variables: blinded administration, animal model, and route of administration. Toxicological Sciences 2001, 60, 295-296. |
| 2000 |
| Banton, M.I.; Tyler, T.R.; Ulrich, C.E.; Nemec, M.D.; Garman, R.H. Subchronic and developmental toxicity studies of n-butyl propionate vapor in rats. J Toxicol Environ Health A 2000, 61(2), 79-105. |
Holson, J.F.; Stump, D.G.; Clevidence, K.J.; Knapp, J.F.; Farr, C.H. Evaluation of the prenatal developmental toxicity of orally administered arsenic trioxide in rats. Food and Chemical Toxicology 2000, 38, 459-466. |
| Stetson, P.; Watson, C.; Husa, C.; Counsell, R.; Draganov, D.; Billecke, S.; La Du, B.N. Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. The American Society for Pharmacology and Experimental Therapeutics 2000, 28(11), 1335-1342. |
| Stump, D.G.; Holson, J.F.; Clevidence, K.J.; Knapp, J.F.; Farr, C.H. Evaluation of the prenatal developmental toxicity of orally administered arsenic trioxide in rats. Food and Chemical Toxicology 2000, 38, 459-466. |
| Padgett, E.L.; Sibley, D.A.; Jerrells, T.R. Effect of adrenalectomy on ethanol-associated changes in lymphocyte cell numbers and subpopulations in thymus, spleen and gut-associated lymphoid tissue. International Journal of Immunopharmacology 2000, 22, 265-298. |
Stetson, P.; Draganov, D.; Watson, C.; Billecke, S.; La Du, B. Rabbit serum paraxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation. Journal of Biological Chemistry 2000, 275(43), 33435-33442. |
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