Publications Abstracts Presentations Book Chapters

2010

Lewis, K.M.; Ferguson, J.; Gleason, T.; Coder, P.  Effects of intraoperatively applied coseal on embryo/fetal development in rats.  The Toxicologist 2010.

2009
Setser, J.J.; Taylor, J.E.; Walker, L.; Lashley, E.L.; Padgett, E.L.  Comparison of rectal, transponder and telemetry thermometry for collection of body temperatures in rats, dogs and monkeys.  AALAS meeting 2009.

Atterson, P.R.; Setser, J.J; Cobb, T.G.; Shellhammer, L.J.; Yohe, J.C.  Biological validation of an external telemetry system in conscious non-human primates.  The American College of Toxicology Meeting 2009.

Atterson, P.R; Kearney, K.R; Gleason, T.R; Edwards, T.R.; Kopp, G.  A new impedance-based method for combined cardio-pulmonary data acquisition in freely moving telemetered animals.  The American College of Toxicology Meeting 2009.

Atterson, P.R.; Voss, K.A.; Kopp, G.  Occurrence and variance of ECG waveform abnormalities in canines and non-human primates:  What is considered normal?  Safety Pharmacology Society Meeting 2009.

Atterson, P.R.;  Kearney, K.R.; Voss, K.A.; Kopp, G.  Combining safety pharmacology endpoints; Impedance based respiratory measurement via implantable telemetry device.  Safety Pharmacology Society Meeting 2009.

Atterson, P.R.;  Roegge, C.S.; Yohe, J.; Landis, K.L.  Evaluation of the effects of Fluoxetine dependency on cardiovascular and withdrawal parameters in rats.  Safety Pharmacology Society Meeting 2009.

Daneshvar, H.; Fleeman, T.; Takacs, K.; Gleason, T.; Stump, D.; Atterson, P.  Development of a model to assess cardiovascular parameters and embryo-fetal development in pregnant rats.  Journal of Pharmacological and Toxicological Methods 2009, 60(2), 250.

Chengelis, C.P.; Kearney, K.R.; Voss, K.; Atterson, P.R. Simultaneous assessment of the safety pharmacology core battery in large animal species.  The Journal of Toxicological Sciences 2009, 34, 181.

Chanda, S.; Lorenz, M.; Wong, B.; Weller, P.; Mertens, J.; Padgett, E.; Peachee, V.; White, K.; Platz, S.  Immunotoxicity testing in rats following 28-day oral exposure to a novel p38 MAP kinase inhibitor.  The Toxicologist 2009, 108, 426.
Atterson, P.R.; Kearney, K.R.; Takacs, K.A.; Barrett, R.; Landis, K.L.  Assessment of the variables affecting rodent respiratory study design and data interpretation.  Journal of Pharmacolgical and Toxicological Methods 2009, 60(2), 216-217.
Bynum, K.S.; Pittman, R.J.; Turson, G.B.; Gleason, T.R.; Edwards, T.R.; Landis, K.L.; Atterson, P.R.  Validation of the rabbit telemetry model for cardiovascular safety pharmacology studies.  Journal of Pharmacological and Toxicological Methods 2009, 60(2), 240.
Daneshvar, H.; Atterson, P.R.; Yohe, J.; Heistand, A.; Landis, K.L.; Chengelis, C.P.  Evaluation of the effects of opiate dependency on cardiovascular parameters in rats.  Journal of Pharmacological and Toxicological Methods 2009, 60(2), 227.
Kearney, K.R.; Voss, K.; Pittman, R.J.; Landis, K.L.; Atterson, P.R.  Comparison of respiratory functional assessment tools using pneumotachograph and respiratory inductance plethysmography.  Journal of Pharmacological and Toxicological Methods 2009, 60(2), 215.
Shellhammer, L.J.; Soloviev, M.V.; Kearney, K.R.; Atterson, P.R.  Effects of body temperature on QT interval in beagle dogs.  Journal of Pharmacological and Toxicological Methods 2009, 60(2), 237-238.
2008
Atterson, P.R.; Soloviev, M.; Kearney, K.; Landis, K.; Castellucci, S.  Intravenous bolus on rat respiratory study:  What is the limit?  Journal of Pharmacological and Toxicological Methods 2008, 58(2), 174.
Atterson, P.R.; Takacs, K.; Schlosser, M.J.  Absence of a pressor response to oral tyramine in conscious telemeterized rats treated with the novel oxazolidinone Tr-701: comparison to linezolid.  ICAAC/IDSA Meeting 2008.
Draganov, D.I.; Teiber, J.F.; Bisgaier, C.L.; Standiford, T.J.; La Du, B.N.  Decreased serum paraoxonase (PON1) and apolipoprotein A-I (apoA-I) levels in critically ill patients with sepsis:  determinants or markers for the severity and outcome.  International Conference on Paraoxonases 2008.
Draganov, D.I.; Nemzek, J.; Teiber, J.F.; Bisgaier, C.L.; Remec, D.; La Du, B.N.  PON1 in murine cecum ligation and puncture (CLP) model of sepsis.  International Conference on Paraoxonases 2008.
Gleason, T.R.; Edwards, T.R.; Miller, W.R.; Sloter, E.D.; Stump, D.G.; Chengelis, C.P.  Ambulatory continuous intravenous infusion model for pregnant Dutch Belted rabbits.  Academy of Surgical Research Meeting 2008.
Teinber, J.F.; Xiao, J.; Kramer, G.L.; Draganov, D.I.; Haley, R.W.  Paraoxonases hydrolyze the iodoeicosanoid -iodolactone and attenuate its antiproliferative activity in cell cultures.  International Conference on Paraoxonases 2008.
Thomas, J.T.; MacElrevey, C.M.; Godsey, J.; Piccirillo, V.J.  In vitro prostate androgen receptor competitive binding assay of propanil (CAS No. 709-98-8).  The American College of Toxicology Meeting 2008.
Atterson, P.A.; Kearney, K.R.; Landis, K.L.; Castellucci, S.; Cockburn, M.  Respiratory assessment in tethered conscious beagle dogs.  Journal of Pharmacological and Toxicological Methods 2008, 58(2), 174.
Lehmen, J.; Ahmed, G.; Kirkpatrick, J.; Harris, W.; Hammond, B.  Safety assessment of SDA soybean oil.  The Toxicologist 2008, 102, 101.

Beck, M.J.; Nemec, M.D.; Stump, D.G.; Holson, J.F.  Design considerations and implications for neurobehavioral data.  The Toxicologist 2008, 102, 355.

Bruner, R.H.; Parker, G.A.; Novilla, M.N.; Picut, C.A.; Kirkpatrick, J.B.; O’Neill, T.P.;   Spontaneous hibernomas in Sprague Dawley rats.  The Toxicologist 2008, 102, 479.

Draganov, D.I.; Johnson, T.J.; Dimond, S.S.; Van Miller, J.  Pharmacokinetics of bis-methylsalicylate carbonate (BMSC) and its hydrolysis/metabolism to methylsalicylate (MS) and salicylic acid (SA) after a single oral (gavage) dose to rats.  The Toxicologist 2008, 102, 199.

Draganov, D.I.; Johnson, T.L.; Mahoney, A.P.; Morfitt, S.J.; Edwards, T.R.; Gleason, T.R.; Miller, W.R.; Sved, D.W.  Metabolism and excretion of 14C-acetaminophen in chronic bile duct cannulated dogs.  Drug Metabolism Reviews 2008, 40(3), 207.

Ehresman, D.J.; Eveland, A.T.; Zitzow, J.D.; Bjork, J.A.; Stump, D.G.; Chang, S.; Wallace, K.B.; Butenhoff, J.L.  Perfluorooctanesulfonate developmental neurotoxicity study in rats.  The Toxicologist 2008, 102, 351.

Knapp, J.F.; Moore, J.S.; Davis, S.M.; Nemec, M.D.; Stump, D.G.; Morita, O.; Tamaki, Y.  A study of the effects of green tea catechins (GTC) on embryo/fetal development in rats.   The Toxicologist 2008, 102, 314.

Lambert, E.A.; Hynick, J.R.; Setser, J.J.; Morris, T.D.; Miller, W.R.; Chengelis, C.P.  The development of an ambulatory continuous infusion method in the nonhuman primate.  Journal of the American Association for Laboratory Animal Science 2008, 47(5), 153.

Parker, G.A.; Picut, C.A.; Scully, K.L.; Veney, D.J.  Histologic features of the developing immune system of rats.  The Toxicologist 2008, 102, 35.

Remick, A.K.; Swanson, C.L.; Scully, K.L.; Roseman, V.C.; Picut, C.A.  Ovarian follicle counting using proliferating cell nuclear antigen (PCNA) and semi-automated image analysis in Sprague Dawley rats. The Toxicologist 2008, 102, 235.

Roegge, C.S.; Evans, A.M.; Beck, M.J.; Atterson, P.R.; Stump, D.G.; Nemec, M.D.; Holson, J.F.  Comparison of training procedures for self-administration of cocaine in female rats.  Neurotoxicology and Teratology 2008, 30(3), 255.

Sawhney Coder, P.; Barrett, R.M.; Varsho, B.J.; Stump, D.G.; Nemec, M.D.; Holson, J.F.  Comparison of fetal malformation and developmental variation rates between Hra:(NZW)SPF rabbits obtained from the Denver or Kalamazoo facilities of Covance Research Products.  Birth Defects Research Part A 2008, 82(5), 353.

Sawhney Coder, P.; Stump, D.G.; Nemec, M.D.; Lampert, B.M.; Trost, L.C.  Developmental toxicity studies in rats and rabbits with CMX001:  a broad-spectrum oral anti-viral agent.  Birth Defects Research Part A 2008, 82(5), 379.

Sloter, E.D.; Nemec, M.N.; Stump, D.G.; Pritt, S.; Beck, M.J.; Gleason, T.R.; Miller, W.R.; Holson, J.F.  Ambulatory continuous intravenous infusion model for pregnant Dutch Belted rabbits.  The Toxicologist 2008, 102, 474.

Weinberg, J.T.; Kirkpatrick, D.T.; Anderson, E.A.; Golias, B.M.; Cockburn, M.S.  Optimization of acclimation and experimental procedures for head-only inhalation exposure of triamcinolone acetonide in Cynomolgus monkeys.  The Toxicologist 2008, 102, 43.

2007

Soloviev, M.V.; Shellhammer, L.J.; Landis, K.L.; Freshwater, L.; Shuey, D.L.  Cardiovascular and pharmacokinetic assessment of morphine in conscious radiotelemetry-implanted beagle dogs.  Journal of Pharmacological and Toxicological Methods 2007, 56(2), 28.

Soloviev, M.V.; Barrett, R.M.; Wally, R.A.; Shellhammer, L.J.; Landis K.L.; Steinbacher, E.A.; Klemm, J.L.; Gumpf, D.S.; Setser, J.J.  Normal variations in hemodynamic parameters and ECG in conscious freely moving telemeterized Cynomolgus monkeys.   Journal of Pharmacological and Toxicological Methods 2007, 56(2), 22.

Soloviev, M.V.; Atterson, P.R.; Barrett, R.M.; Birchmeier, P.A.; Shellhammer, L.J.; Landis K.L.; Wally, R.A.; Chengelis, C.P.  Comparison of two major in vivo cardiovascular safety pharmacology models.   Journal of Pharmacological and Toxicological Methods 2007, 56(2), 27.

Stump, D.G.; ILSI Research Foundation Developmental Toxicity Database Working Group.  A robust developmental toxicity database: live prototype demonstration.  Birth Defects Research Part A 2007, 79, 419.

Sawhney, P.; Birchmeier, P.A.; Varsho, B.J.; Stump, D.G.; Nemec, M.D.; Holson, J.F.  A comparison of maternal growth curves and reproductive parameters between HRA:(NZW)SPF rabbits obtained from the Devnver Kalamazoo facilities of Covance Research Products.  Birth Defects Research Part A 2007, 79, 415.
Radovsky, A.E.; Chengelis, C.P.; Edwards, T.R.; Herberth, M.  Histopathologic and neurobehavioral evaluation of a standardized fluid percussion model of brain trauma in the rat.   Journal of Neuropathology and Experimental Neurology 2007, 66(5), 448.
Draganov, D.I. Human PON3, effects beyond the HDL:  clues from human PON3 transgenic mice.  Circulation Research - Journal of the American Heart Association 2007, 100, 1104-1105.
Bowman, C.J. Toxicology of the female reproductive tract in standard fertility study designs (WS2-2). The Journal of Toxicological Sciences 2007, 32, S51.
Kirkpatrick, D.T.; Thullen, T.D.; Farr, C.H.; Nemec, M.D.; Sloter, E.D.; Weedman, K.L.; Davis, S.; Sherman, J.; Foster, K.C.  The effects of inhaled vapors of dimethyl disulfide on embryo/fetal development in rats and rabbits.  The Toxicologist 2007, 96, 92.
Weinberg, J.T.; Kirkpatrick, D.T.; Wallhead, R.W.; Gumpf, D.S.; Lambert, J.  Respiratory measurement validation study in Cynomolgus monkeys using a head plethysmograph:  effects of morphine (IV) and histamine.  The Toxicologist 2007, 96, 100.
Beck, M.; Nemec, M.D.; Kirkpatrick, D.T.; Tanchevski, E.; Ogg, J.P.; Varsho, B.J.; Bowman, C.J.; Farr, C.   The neurological assessment of acute and subchronic inhalation exposure of dimethyl disulfide (DMDS) in CRL:CD rats.  The Toxicologist 2007, 96, 187.
Chengelis, C.P.; Kirkpatrick, J.; Regan, K.S.; Radovsky, A.E.;  Morita, O.; Tamaki, Y.; Suzuki. H.   28-day oral (gavage) toxicity studies in rats of green tea catechins prepared for beverages.  The Toxicologist 2007, 96, 298.
Nemec, M.D.; Kirkpatrick, D.T.; Sawhney, P.; Knapp, J.F.; Sherman, J.; Tanchevski, E.; Donahue, D.A.; Petruzzi, E.E.; Farr, C.H.   A two-generation reproductive toxicity and lactational inhalation-phase exposure study of dimethyl disulfide in rats.  The Toxicologist 2007, 96, 312.
Mertens, J.J.W.M; Sved, D.W.; Marit, G.B.;  Myers, N.R.; Stetson, P.L.; Murphy, S.R.; Schmit, B.; Shinohara, M.;  Farr, C.H.  A 90-day oral (gavage) toxicity study of S-111-S-WB with a 60-day recovery period in Sprague Dawley rats.  The Toxicologist 2007, 96, 313.
Stump, D.G.; Holson, J.F.; Murphy, S.R.;  Farr, C.H.; Schmit, B.;  Shinohara, M.  An oral two-generation reproductive toxicity study of S-111-S-WB in rats.  The Toxicologist 2007, 96, 425.
Siddiqui, W.H.; Stump, D.G.; Kirkpatrick, D.T.; Knochel, J.L.; Crofoot, S.D.; Plotzke, K.P.  Evaluation of Hexamethyldisiloxane (HMDS) in a 2-generation reproductive toxicity study in rats.  The Toxicologist 2007, 96, 426.
Sloter, E.D.; Siddiqui, W.H.; Stump, D.G.; Plotzke, K.P.  28-day oral and reproductive/developmental screening toxicity studies of Vinyl-Tris(2-Methoxyethoxy) Silane.   The Toxicologist 2007, 96, 426.
2006

O’Neill, T.P.; Tarantino, P.; Chengelis, C.P.; Herberth, M.; Lee, M. Biomarkers of isoproternol-induced cardiac damage.  The Toxicologist 2006, 90, 444.

Kirkpatrick, D.T.; Weinberg, J.T.  Measurement and prediction of juvenile Beagle respiratory parameters for use in inhalation dosimetry estimates.  The Toxicologist 2006, 90, 347.

Siddiqui, W.H.; Stump, D.G.; Holson, J.F.; Kirkpatrick, D.T.; Plotzke, K.P.  An inhalation F1 generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats.  The Toxicologist 2006, 90, 253.

Nemec, M.D.; Kirkpatrick, D.T.; Sherman, J.; Van Miller, J.P.; Strother, D.E.  The effects of inhaled vapors of acrylonitrile on rat reproduction over two successive generations.  The Toxicologist 2006, 90, 251.

Sands, S.A.; DiRienzo, M.A.; Eapen, A.K.; Harris, W.S.  Stearidonic acid increases red blood cell and cardiac levels of EPA, but not DPA or DHA, in dogs.  Federation of American Societies for Experimental Biology Journal 2006, 20, A1028.

Sheets, L.P.; Nemec, M.D.; Breckenridge, C.; Creek, M.; Mullen, L.; Sargent, D.; Sharp, J.; Weiner, M.  An acute-exposure functional observational battery comparison study of 12 pyrethroids in rats.  The Toxicologist 2006, 90, 10.
2005
Schaefer, G.J.; Soloviev, M.V.; Gleason, T.R.; Edwards, T.R.; Altschuler, R.A.; Dolan, D.F.; Prieskorn, D.M.  A 14-day ototoxicity study using neomycin in the guinea pig.  Safety Pharmacology Meeting 2005.

Soloviev, M.V.; Wilkinson, J.T.; Shellhammer, L.J.; Wally, R.A.; Barrett, R.M.; Birchmeier, P.A.; Schaefer, G.J.  Normal variations in hemodynamic parameters and ECG in conscious freely moving telemeterized beagle dogs.  Safety Pharmacology Society Meeting 2005.

Meeks, R.G.; Jean, P.A.; Mertens, J.W.M.; Regan, K.S.; Crissman, J.W., Plotzke, K.P.  Chronic toxicity and oncogenicity study of Polydimethylsiloxane (PDMS) 10 CST fluid in Fischer 344 rats.   The Toxicologist 200584, 308.
Soloviev, M.V.; Taylor, M.J.; Edwards, T.R.; Culwell, J.; Rampersand, C.R.; Filice, J.A.; Argonza, D.; Calimlim, M.; Ordonio, R.; Afan, R.; Siacotos, T.J.; Schaefer, G.J.  Use of naltrexone to prevent adverse effects of sufentanil in beagle dogs.  The Toxicologist 2005, 84, 96.
Sloter, E.D.; Nemec, M.D.; Baumgartner, R.; Holson, J.F.; Gargas, M.; Kirkpatrick, D.T.; Kinzell, J.  Methyl iodide-induced hypothyroidism in fetal rabbits.  The Toxicologist 2005, 84, 50.

Nemec, M.D.; Sloter, E.D.; Holson, J.F.; Stump, D.G.; Kinzell, J. Prenatal developmental toxicity studies in rabbits reveal a susceptible window of methyl iodide-induced fetotoxicity late in gestation.  The Toxicologist 2005, 84, 50.

Varsho, B.J.; Stump, D.G.; Holson, J.F.; Clevidence, K.J.; Kopp, C.A.; Nussbaum, J.M.; Nemec, M.D.  A comparison of reproductive parameters between artificially inseminated and naturally mated Hra:(NZW)SPF rabbits. Birth Defects Research Part A 2005, 73, 354.

Soloviev, M.V.; Gleason, T.R.; Wilkinson, J.; Shellhammer, L.J.; Edwards, T.R.; Wally, C.S.; Miller, W.R.; Schaefer, GJ.  Effects of general anesthesia with telazol on the myocardial contractility in beagle dogs.   Safety Pharmacology Meeting 2005.
Soloviev, M.V.; Smith, K.J.; Shellhammer, L.J.; Schaefer, G.J.  Effects of plethysmograph restraint and dosing on respiratory parameters in rats. Safety Pharmacology Meeting 2005.
Soloviev, M.V.; Gleason, T.R.; Wilkinson, J.T.; Edwards, T.E.; Shellhammer, L.E.; Radovsky, A.E.; Schaefer, G.J.  Radiotelemetry monitoring of urinary bladder activity in rats.  Safety Pharmacology Meeting 2005.
McKee, R.H.; Pavkov, K.L.; Trimmer, G.W.; Keller, L.H.; Stump, D.G.  Developmental and reproductive toxicity of di-isoheptyl phthalate in rodents.  The Toxicologist 2005, 84, 57.
Nuber, D.C.; Weiner, M.L.; Harriman, J.F.; Cohen, S.M.  A 90-Day dietary study on Carrogeenan with emphasis on the gastrointestinal tract.  The Toxicologist 200584, 286.

Beck, M.J.; Nemec, M.D.; Kirkpatrick, D.T.; Holson, J.F.; Lewis, S.A.; Piccirillo, V.J.; McAllister, D.  A method for simultaneous whole-body inhalational (inh.) exposure of lactating rats and offspring.  Birth Defects Research Part A Clinical and Molecular Teratology 2005, 73, 5.

2004

Soloviev, M.V.; Taylor, M.J.; Mertens, J.J.W.M.; Schaefer, G.J.; Wilkinson, G.T.; Edwards, T.R.; Chengelis, C.P.  Continuous evaluation of subcutaneous temperature in rats.  10th International Congress of Toxicology 2004.

Shuey, D.L.; Carliss, R.; O’Neill, T.P.; Radovsky, A.; Gerson, R.J.  Dextromethorphan does not cause neuronal vacuolation or degeneration in the posterior cingulate/retrosplenial cortex of rats.  The Toxicologist 2004, 78 (1-S), 62.

Smith, K.J.; Lake-Bruse, K.D.; Bodine, R.E.; Freshwater, L.; Hoffman, W.; Kallman, M.J.; Wolff, R.K.; Schaefer, G.J.  Pulmonary and arterial blood gas assessment of bethanecholin plethysmograph-restrained rats.  Safety Pharmacology Meeting 2004.

Bowman, C.J.; Turner, K.J.; Sar, M.; Barlow, N.J.; Gaido, K.W.; Foster, P.M.D.  Altered gene expression during rat wolffian duct development following di (n-butyl) phthalate exposure.  Teratology Society Meeting 2004.

Bu, W.; Freer, D.S.; Hollar, S.M.; Stetson, P.L.; Boyd, R.B.; Sved, D.W.  Direct analysis of a peptide AM336 in monkey cerebrospinal fluid by LC/MS with a mixed – function column.  ASMS Conference on Mass Spectrometry and Allied Topics 2004.
Smith, K.J.; Soloviev, M.V.; Schaefer, G.J.  Changes in rat respiratory parameters in response to placement in buxco plethysmograph.  Safety Pharmacology Society Meeting 2004.

Varsho, B.J.; Edwards, R.J.; Obringer, D.J.; Bowman, C.J.; Stump, D.G.; Nemec, M.D.  An analysis of pregnancy rates from prenatal developmental toxicity studies in artificially inseminated HRA: (NZW) SPF rabbits conducted during an eight-year period.  Birth Defects Research Part A 2004, 70(5), 323.

Pruett, S.B.; Padgett, E.L.  Thymus-derived glucocorticoids are insufficient for normal thymus homeostasis in the adult mouse.  BMC Immunology 2004, 5, 24.
Beck, M.J.; Ching, S.V.; Leung, E.; Moorman, A.R.; Lai, A.A.; Radovsky, A.; Buelke-Sam, J.  An acute toxicity and pharmacokinetic study of the ACE inhibitor, ramipril (R), in juvenile rats.  Birth Defects Research Part A Clinical and Molecular Teratology 200470, 294.
2003
Chengelis, C.P.; Kirkpatrick, J.B.; Marit, G.B.; Morita, O.;  Tamaki, Y.; Suzuki, H.  Chronic dietary toxicity study of DAG (Diacylglycerol) in beagle dogs.  The Toxicologist 2003, 72(S-1), 253-254.
Beck, M.J.; Gleason, T.R.; Wally, C.A.; Chengelis, C.P.; Stump, D.G.; Nemec, M.D.  Continuous infusion as a route of administration in embryo/fetal development studies in the rabbit.  The Toxicologist 2003, 72(S-1), 327.
Holson, J.F.; Pearce, L.B.; Stump, D.G.  A probable false positive finding of prenatal toxicity in the rodent model with a high molecular weight protein oxygen therapeutic:  evidence and implications.  Birth Defects Research Part A 200367(5), 345.
Beck, M.J.; Stump, D.G.; Nemec, M.D.; Holson, J.F.; Tizzano, J.P.; Buelke-Sam, J.; Developmental toxicity studies in rats and rabbits with DOV 21,947:  A triple reuptake inhibitor.  Birth Defects Research B 200368, 231.
O’Neill, T.P.; Chengelis, C.P.; Haley, S.C.; Piccirillo, V.J.  Validation of the IL 682 co-oximeter for evaluation of methemoglobin in the Sprague Dawley rat.  The Toxicologist 2003, 72(S-1), 32.
Harriman, J.F.; Padgett, E.L.; Kirkpatrick, D.T.; Haas, M.C.; Wilkinson, J.T.; Chengelis, C.P. Caloric restriction reduces body fat, lean muscle mass, and palpable masses while increasing the 24-month survival rate in Sprague Dawley rats.  The Toxicologist 2003, 72(S-1), 211.
Schaefer, G.J.; Kirkpatrick, D.T.; Holson, J.F.; Chengelis, C.P.; Regan, K.S.; Piccirillo, V.J.  A six-week inhalation neurotoxicity study of methyl bromide in dogs.  The Toxicologist 200372 (S-1), 304.
2002
Smith, K.J.; Wilkinson, J.T.; Lake-Bruse, K.D.; Schaefer, G.J.; Chengelis, C.P.  Pulmonary and telemetry cardiovascular assessment of an escalating dose of d amphetamine sulfate in Rats.  Safety Pharmacology Society Meeting 2002.
David, R.M.; Stump, D.G.; Miller, K.R.  Lack of developmental toxicity in SD Rats with Di(2-ethylhexyl)terephthalate (DEHT, DOTP). The Toxicologist 200266(1-S), 234.
Faber, W.D.; Stump, D.G.; David, R.M.; Miller, K.R.  Lack of reproductive toxicity in a 2-generation study of Di(2 ethylhexyl)terephthalate (DEHT, DOTP) in rats.  The Toxicologist 200266(1-S), 371.
Byrd, R.A.; Hilbish, K.G.; Morford, L.L.; Hollandbeck, M.S.; Mace, K.F.; Stump, D.G.  Reproductive and developmental toxicity studies in rats and rabbits with LY307161 SR, a sustained-release formulation of a dipeptidyl peptidase-IV (DPP-IV) resistant glucagon-like peptide 1 (GLP-1) analog.  Teratology 2002, 65, 339.
Stump, D.G.; Nemec, M.D.; Wally, C.S.; Chengelis, C.P.  Embryo/fetal developmental toxicity studies in dogs via intravenous jugular vein infusion.  The Journal of Toxicological Sciencies 2002, 27, 390.
Phelka, A.D.; Beck, M.J.; Philbert, M.A.  Potential role of mitochondrial complex II in the differential CNS sensitivity to 1,3-dinitrobenzene-induced encephalopathy.  The Toxicologist 2002, 66(1-S), 13.
Smith, K.J.; Wilkinson, J.T.; Lake-Bruse, K.D.; Schaefer, G.J.; Chengelis, C.P.  Pulmonary and telemetry cardiovascular assessment of an escalating dose of d-amphetamine sulfate in rats.  Safety Pharmacology Society Meeting, 2002.
Padgett, E.L.; Chengelis, C.P.; Rhodes, K.K.; Holbrook, D.L.; Haas, M.C.; Lehman, J.L.; Bell, C.R.; Nemec, MD.  Postpartum developmental reference data from beagle dogs over four defined pediatric stages.  The Toxicologist 200266(1-S), 236.
O’Neill, T.P.; Bu, W.; Chengelis, C.P.; Myers, N.; McCarty, J.D.; Stetson, P.L.; Sved, D.  Simultaneous determination of six urinary porphyrins in the untreated beagle dog using liquid chromatography–tandem mass spectrometry. The Toxicologist 2002, 66(1-S), 352.
Schaefer, G.J.; Nemec, M.D.; Herberth, M.T.; Pitt, J.A.; Radovsky, A.E.; Knapp, J.F.  Validation of developmental neurotoxicity endpoints in rats administered methimazole in drinking water.  The Toxicologist 200266(1-S), 234.
Chengelis, C.P.; Padgett, E.L.; Rhodes, K.K.; Frey, R.; Simons, M.L.; Schaefer, G.J.; Nemec, M.D.  Performance validation and demonstration of the sensitivity to detect drug induced alterations using a locomotor activity system for large animals. The Toxicologist 200266(1-S), 263.
Sandberg, J.A.; Jackson, T.E.; Caputo, F.A.; Padgett, E.L.; Lee, P.A.  Safety of a ribozyme targeting HER2 receptor mRNA (HERZYUMETM) in CD-1 Mice and Cynomolgus monkeys following daily bolus subcutaneous injections for 29 Days.  The Toxicologist 2002, 66(1-S), 323.
Beck, M.J.; Nemec, M.D.; Schaefer, G.J.; Stump, D.G.; Buelke-Sam, J.  Validation of peripheral tissue Cholinesterase activity assessment in rats administered Chlorpyrifos by gavage.  Teratology 2002, 65, 327.
Pitt, J.A.; Snyder, L.T.; Smith, B.L.; Varsho, B.J.; Nemec, M.D.; Holson, J.F.  An X-Ray study of the incidence of supernumerary ribs and presacral vertebrae in adult rats, mice and rabbits.  Teratology 2002, 65, 328.
2001
Schaefer, G.J.; Wilkinson, J.T.; Bruse, K.D.; Herberth, M.T.; Chengelis, C.P.  Use of radiotelemetry to detect changes over time of blood pressure, heart rate and electrocardiogram in rats and dogs following oral administration of isoproterenol and propranolol.  Safety Pharmacology Society Meeting 2001.
Stewart, B.E.; Stump, D.G.; Johnson, P.A.; Working, P.K.  Methylphenidate HCL is not a developmental toxicant in the rat.  The Toxicologist 2001, 60, 219-220.
Morford, L.L.; Stump, D.G.; Stank, K.K.; Garner, C.O.; Byrd, R.A.  A prenatal and postnatal (segment III) toxicology study in rats with LY333531, a potent and selective protein kinase C-B inhibitor.  Teratology 2001, 63, 290.
Schaefer, G.J.; Wilkinson, J.T.; Chengelis, C.P.  A comparison of heart rate and blood pressure changes in dogs and rats produced by the acute oral administration of isoproterenol and propranolol.  The Toxicologist 2001, 60, 15.
Knapp, J.; Herberth, M.; Schaefer, G.; Chengelis, C.  Safety pharmacology: central nervous system assessment of diazepam in male mice.  The Journal of Toxicological Sciences 2001, 26(4), 260.
Padgett, E.L.; Sandberg, J.A.; Jackson, T.E.; Lee, P.A.  Safety assessment of a novel ribozyme motif (herzyme) in mice following a single intravenous or subcutaneous bolus injection.  The Toxicologist 2001, 60, 320.
Cragin, D.W.; Mertens, J.W.M.; Yarrington, J.T.; Salmona, M.; Ciocca, P.; Bui, Q.Q.  Absence of neurotoxicity for tricyclohexyltin hydroxide in a 90-day feeding study in rats.  American College of Toxicology Meeting 2001.
Varsho, B.J.; Stump, D.G.; Becker, R.A.; Owens, J.W.  OECD rodent uterotrophic assay validation variables: blinded administration, animal model, and route of administration. Toxicological Sciences 2001, 60, 295-296.
2000

Siddiqui, W.H.; Stump, D.G.; Reynolds, V.L.; Kirkpatrick, D.T.; Holson, J.F.; Meeks, R.G. One generation inhalation reproductive toxicity study of hexamethyldisiloxane (HMDS) in rats.  The Toxicologist 2000, 54, 368.

Stump, D.G.; Holson, J.F.; Kirkpatrick, D.T.; Reynolds, V.L.; Siddiqui, W.H.; Meeks, R.G. Evaluation of octamethylcyclotetrasiloxane (D4) in a 2-generation reproductive toxicity study in rats. The Toxicologist 2000, 54, 370.

O’Neill, T.P.; Ayers, M.S.; Rossignol, J.F.; Zimmer, E.P.; Ciofalo, E.B.; Spainhour, C.B.  Chrysalis Preclinical Services, The Twenty-Eight Day Oral Toxicity of Nitazoxanide in the Canine.  The Toxicologist 2000, 54, 408.
Varsho, B.J.; Cappon, G.D.; Kirkpatrick, D.T.; Welter, D.C.; Obrecht, J.C.; Feikert, T.D.  A study of the effects of restraint duration for nose-only inhalation exposure on embryo/fetal development in rats.  Toxicological Sciences 2000, 54, 204.